ABSTRACT
As micoses superficisis säo as infecçöes mais comuns do tegumento cutâneo, envolvendo as partes queratinizadas, semiqueratinizadas, mucosas e os anexos pêlos e unhas.(au)
Subject(s)
Humans , Male , Adult , Antacids/administration & dosage , Antacids/adverse effects , Antiemetics/administration & dosage , Antiemetics/adverse effects , Antiemetics/pharmacology , Dyspepsia , Helicobacter pyloriSubject(s)
Humans , Acute Disease/therapy , Antacids/therapeutic use , Evaluation of Results of Therapeutic Interventions/methods , Gastrointestinal Hemorrhage/prevention & control , Histamine H2 Antagonists/adverse effects , Research/methods , Misoprostol/therapeutic use , Prospective Studies , Risk Factors , Sucralfate/therapeutic use , Algorithms , Antacids/adverse effects , Gastrointestinal Hemorrhage/epidemiology , Gastrointestinal Hemorrhage/mortality , Histamine H2 Antagonists/economics , Treatment OutcomeABSTRACT
In this study, the dissolution rate of frusemide as a sparingly soluble diuretic, was determined in the presence of some commercial antacids. The effect of tea, as a conventional drink, on the in vitro availability of the drug in the presence of the selected antacids was also investigated. The obtained results revealed that, availability of frusemide was markedly affected in the presence of the selected antacids. The powdered antacids showed the most prominent effect, while antacid tablets produced the lowest in this respect. Also, a marked reduction in the dissolution rate of frusemide was observed in the presence of both tea and antacids. The observed reduction in the dissolution rate of frusemide with these antacids may be attributed to the chemical interaction, which was proved by IR, UV and TLC studies
Subject(s)
Furosemide/pharmacokinetics , Biological Availability , Antacids/adverse effects , Drug InteractionsABSTRACT
The bioavailability of frusemide [FR] after oral administration of FR alone or FR with antacids or FR with antacids and tea drink was investigated using rabbits. The urinary excretion rate was monitored and drug concentrations were compared. The results revealed that the drug bioavailability was markedly reduced in the presence of the selected antacids, viz. Neogelco and Simeco suspensions, and Stomaclin powder. A significant reduction was recorded in both the total cumulative amount excreted over 24 h [P <0.05] and the excretion rate of the drug [P <0.01]. Tea drink was found to have an influence on FR absorption, if taken concurrently with the tested antacids. With Stomaclin powder, tea drink significantly [P <0.01] increased the biological availability of FR compared with that obtained with antacid alone, while such effect in case of Neogelco suspension was insignificant [P >0.05]. With Simeco suspension, however, tea drink significantly [P <0.01] reduced the biological availability of FR
Subject(s)
Furosemide/pharmacokinetics , Biological Availability , Antacids/adverse effects , Drug InteractionsABSTRACT
Revisamos prospectivamente las historias clínicas de 100 pacientes consecutivos que ingresaron por emergencia de un hospital general el primer tremestre de 1991, para determinar fármacos más frecuentemente usados y sus interacciones utilizando un programa computarizado (Drug Interaction Program) haciendo énfasis en medicamentos antiulcerosos. El número de drogas indicada por pacientes fue 4.29 ñ 1.39. Los antiácidos (39%) y la cimetidina (35%) ocuparon el tercero y cuarto lugar. Hubo interaciones en 79 pacientes y en 66 (84%) fueron importantes, promediandose 2.44 ñ 2.13 interacciones por paciente. Los antiácidos y la cimetidina fueron igualmente indicados, de 35 pacientes que recibieron cimetidina 3 (8.5%) tenían indicación primaria de su uso (Hemorragia Digestiva). La interacción clínica de la cimetidina con otros medicamentos es analizada. Nuestros resultados indican que las interacciones medicamentosas son un riesgo permanente en nuestros hospitales. Sugerimos la utilización de un programa computarizado de interacciones medicamentosas o una tabla actualizada de medicamentos en las emergencias de nuestros hospitales
Subject(s)
Adolescent , Adult , Middle Aged , Humans , Male , Female , Drug Monitoring , Histamine H2 Antagonists/adverse effects , Aged, 80 and over , Antacids/adverse effects , Cimetidine/adverse effects , Drug Interactions , Emergencies , Prospective StudiesSubject(s)
Adult , Akathisia, Drug-Induced , Antacids/adverse effects , Antiemetics/adverse effects , Dopamine Antagonists , Duodenal Ulcer/drug therapy , Dyskinesia, Drug-Induced/etiology , Dystonia/chemically induced , Female , Histamine H2 Antagonists/adverse effects , Humans , Receptors, Dopamine/drug effects , Time FactorsABSTRACT
Se hace una revision del tratamiento de la enfermedad acidopeptica, definiendo para el efecto, las drogas existentes y su utilidad. Se clasifican en aquellas que modfician el factor acido (antiacidos, anticolinergicos, antogonistas de los receptores H2 y los Benzimidazoles sustitiudos), las que aumentan la resistencia (sucralfate, bismutos y carbenoxolona), y otras (tranquilizantes y neurolepticos y las prostaglandinas). Se discuten los esquemas terapeuticos utilizados. Finalmente se hacen algunas anotaciones sobre la importancia que tiene la cirugia en el tratamiento de la enfermedad acidopeptica